[摘要]：We report herein synthesis and antimicrobial activity of a series of N,N-dibenzyl-cyclohexane-1, 2-diamine derivatives. In order to study the structure activity relationship of substituted dibenzylcyclohexane-1,2-diamine derivatives, 44 structurally diverse compounds were synthesized and tested against Gram-positive and Gram-negative bacterial strains. Among them, compounds 17-20, 26, 37, 38 were found to be more active than tetracycline with MIC value ranging 0.0005-0.032 mu g/mL and no hemolysis upto 1024 mu g/mL in mammalian erythrocytes was observed. Some of the compounds have also shown very promising antifungal activity against Candida albicans, Candida glabrata and Geotrichum candidium. (C) 2010 Elsevier Masson SAS. All rights reserved.
