Efficient Synthesis of Nicotianamine and Non-Natural Analogues

[摘要]：An efficient synthesis of nicotianamine has been achieved by using a new strategy based on N-alkylation. Sulfonamide activation proved to be necessary for the alkylation of the primary amine and the 2-(trimethylsilyl)ethanesulfonyl group was easily introduced and found to provide the best compromise for the N-alkylation and deprotection reactions. This new strategy enabled the preparation of several unnatural analogues including original molecules that will be useful as tools for plant physiology studies.

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