Uncatalyzed One-Pot Diastereoselective Synthesis of alpha-Amino Phosphonates Under Solvent-Free Conditions

[摘要]：Uncatalyzed one-pot, three-component reactions of aldehydes, chiral alpha-methylamines, and dimethyl phosphite under solvent-free conditions were used for the diastereoselective synthesis of alpha-amino phosphonates. The reactions proceeded with extremely high efficiency under mild conditions and gave good yields and diastereoselectivities (70:30 to 93:7 dr). This approach could be useful for the large-scale synthesis of several alpha-amino phosphonates.

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