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The Use of a Single Derivative in the Configurational Assignment of Ketone Cyanohydrins

  作者 LOUZAO IRIA; SECO JOSE M; QUINOA EMILIO; RIGUERA RICARDO  
  选自 期刊  European Journal of Organic Chemistry;  卷期  2010年-34;  页码  6520-6524  
  关联知识点  
 

[摘要]The absolute stereochemistry of ketone cyanohydrins can be easily determined by preparing a single MPA derivative. The comparison of two NMR spectra at different temperatures allows the assignment by just paying attention to the evolution of the cyanohydrin chemical shifts. The special case of alpha-aryl-substituted cyanohydrins is also described.

 
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