Palladium-catalyzed amino-Heck reaction of g,d-unsaturated ketone O-diethylphosphinyloximes: a new synthesis of substituted pyrroles and indoles.

[摘要]：g,d-Unsatd. ketone O-diethylphosphinyloximes I (R = Ph, 2-naphthyl, 4-MeOC6H4, pyridin-4-yl, etc.), readily prepd. from the corresponding ketones, were used as starting materials for the intramol. amino-Heck reactions. In the presence of a catalytic amt. of Pd(PPh3)4 in DBU, cyclization reactions occurred preferentially via a 5-exo fashion to afford a variety of 2-substituted 5-methyl-1H-pyrroles, e.g., II. Cyclic derivs. of I, e.g., III, were demonstrated to offer a synthetic route to the corresponding indole derivs.

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