[摘要]：Background: The principal objective of this study was to evaluate the prognostic significances of p53, hypoxia inducible factor-1 alpha (HIF-1 alpha), and vascular endothelial growth factor (VEGF) expression in colorectal cancer. Materials and Methods: The tumor tissues of 311 patients with colorectal carcinoma that had undergone potentially curative resections were immunohistochemically assessed using monoclonal antibodies against p53, HIF-1 alpha, and VEGF. Results: Positivity rates of p53, HIF-1 alpha, and VEGF were 42.4%, 63.0%, and 56.6%, respectively. HIF-1 alpha expression in tumor tissues was determined to be correlated significantly with the expression of VEGF (p=0.040), and depth of invasion (p=0.019). Multivariate analysis demonstrated that HIF-1 alpha was independently associated with poor overall survival (p=0.002). Conclusion: HIF-1 alpha expression is associated with VEGF expression and angiogenesis in colorectal carcinoma. Additionally, the expression of HIF-1 alpha in tumor tissue is associated with angiogenesis and poor overall survival in patients with colorectal cancer.
