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Studies with 2-(Acetonylthio)benzothiazole: Novel Synthesis of Pyridazin-6(1H)-one, Pyridazin-6(1H)-imine, and Phthalazine Derivatives of Antimicrobial and Antifungal Activities

  作者 ALOMRAN FATIMA A; ELKHAIR ADEL A  
  选自 期刊  Journal of Heterocyclic Chemistry;  卷期  2011年48-2;  页码  241-248  
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[摘要]A novel series of (Z)-1-(arylhydrazono)-1-(benzothiazol-2'-ylthio)propan-2-ones have been prepared and their utility as building blocks in the synthesis of novel derivatives of Pyridazin-6(1H)-ones, pyridazin-6(1H)-imines, and phthalazine incorporating a benzothiazole residue are investigated. All of the title compounds were confirmed by elemental analysis, IR, H-1 NMR, C-13 NMR, NOE, and mass spectrometry. The synthesized compounds are screened for their antibacterial as well as antifungal activity. All the tested. compounds showed high to moderate activity against the selected microorganisms.

 
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