Synthesis and In Vitro Antibacterial Assessment of Novel Chromones Featuring 1,2,4-Oxadiazole

[摘要]：In search for a new antibacterial agent with improved antimicrobial spectrum and potency, we designed and synthesized a series of novel 3-((Z)-2-(5-methyl-1,2,4-oxadiazol-3-yl)-2-(4-nitrophenyl)-vinyl)-4H-chr omen-4-ones (7a-h) by convergent synthesis approach. All the synthesized compounds were assayed for their in vitro antibacterial activities against gram-negative and gram-positive bacteria. The preliminary structure-activity relationship to elucidate the essential structure requirements for the antimicrobial activity has been described.

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