NOVEL SYNTHESIS OF CARBOCYCLIC OXETANOCIN ANALOGS (2-ALKOXY-C.OXT-A) AND THEIR TUBE FORMATION ACTIVITIES OF HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (HUVEC)

[摘要]：We succeeded in the effective synthesis of five types of 2-alkoxy-C.OXT-A analogs (9, 10a-d) by applying the de novo synthesis of 2-alkoxyadenosine derivatives (2), which was developed in our laboratory. For these synthesized compounds, the angiogenic activity was evaluated using human umbilical vein endothelial cells. Four products (10a-d) enhanced the activity of the cell; in particular, 2-methoxy-C.OXT-A (10a) and 2-isopropoxy-C.OXT-A (10c) at a concentration of 100 mu M exhibited the same or stronger potency than the vascular endothelial cell growth factor.

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