SYNTHESIS OF 1-AMINO-1-ARYL-1,2-DIHYDROPYRROLO[3,4-c]PYRIDIN-3-ONE DERIVATIVES BY THE REACTION OF 4-LITHIOPYRIDINE-3-CARBONITRILE WITH AROMATIC TERTIARY AMIDES

[摘要]：A one-pot procedure for the preparation of 1-amino-1-aryl-1,2-dihydropyrrolo[3,4-c]pyridin-3-one derivatives from pyridine-3-carbonitrile and aromatic tertiary amides has been developed. Thus, the reaction of 4-lithiopyridine-3-carbonitrile, generated by the treatment of pyridine-3-carbonitrile with lithium 2,2,6,6-tetramethylpiperidide (LIMP), with aromatic tertiary amides in THF at -78 degrees C yields the pyrrolopyridinone derivatives in moderate yields.

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