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Debenzylation of Functionalized 4-and 5-Substituted 1,2,3-Triazoles

  作者 FAROOQ TAHIR; SYDNES LEIV K; TORNROOS KARL W; HAUG BENGT ERIK  
  选自 期刊  Synthesis;  卷期  2012年44-13;  页码  2070-2078  
  关联知识点  
 

[摘要]A range of 4- and 5-substituted N-benzyl-1,2,3-triazoles have been submitted to debenzylation using Pd/C and hydrogen in the presence of 1,1,2-trichloroethane. Triazoles with oxygen-containing substituents are efficiently debenzylated under these conditions. Triazoles with a phenyl or benzyl substituent on C4 or C5 are not debenzylated, whereas a pentyl-substituted derivative was readily debenzylated.

 
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