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[摘要]：The microwave-assisted Wolff rearrangement of cyclic 2-diazo-1,3-diketones in the presence of primary amines and alpha beta-unsaturated aldehydes provides a straightforward three-component stereoselective access to a variety of alpha-spiro-beta-lactams following an imination/Wolff rearrangement/[2 + 4] cycloaddition domino sequence. With aniline derivatives, a complementary aza-Wittig/Wolff rearrangement/[2 + 4] sequence was developed. These reactions feature an unprecedented reactivity of acylketenes as dienophiles in 6 pi electrocyclic processes. |
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