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[摘要]:The total synthesis of potent immunosuppressant FR901483 (1) is reported. The remarkable feature of our convergent synthesis is the p-methoxybenzyl and methylamino groups are stereoselectively incorporated within the tri-cyclic core skeleton. The skeleton itself is constructed by an intramolecular aldol reaction on a symmetrical keto-aldehyde (14), which is readily derived by an eight-step sequence from nitromethane and methyl acrylate. |
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