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[摘要]:5H-Thiazolo[3,2-a]pyrimidin-5-ones were easily prepared in good to excellent yields with high regioselectivity by nucleophilic addition of thiazol-2-amines to Morita-Baylis-Hillman adduct acetates, followed by cyclization and a thermo-sigmatropic shift procedure under solvent-free and base-free conditions. |
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