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[摘要]：(A) Boruah and co-workers(3) reported an efficient synthesis of indolizines in excellent yields via a microwave-mediated, one-pot, three-component reaction of 2-bromoacetophenone, pyridine, and acetylene, catalyzed by basic Al2O3. [GRAPHICS] (B) Yadav et al. reported vic-diallylation and dipropargylation of 2-bromoacetophenone with allyl and propargyl indium reagents, generated in situ from metallic indium and allyl or propargyl bromide to produce 4-aryl-octa-1,7-dien-4-ol derivatives in good yields.(4) [GRAPHICS] (C) Das et al.(5) developed a convenient method for the rapid and high-yielding synthesis of thiazoles and amino thiazoles by treatment of 2-bromoacetophenone with thioamides or thiourea in the presence of ammonium-12-molybdophosphate (AMP) at room temperature. [GRAPHICS] (D) An efficient synthetic procedure for fused 2,3-dihydrofuran derivatives was developed by Chao-Guo Yan and co-workers(6) with the assistance of pyridinium ylide. A sequential one-pot, two-step tandem reaction starting from pyridine, aromatic aldehyde, dimedone or 4-hydroxy coumarin and 2-bromoacetophenone with triethyl amine as catalyst proceeded smoothly in acetonitrile. [GRAPHICS] (E) Anabha and co-workers(7) reported the synthesis of substituted 2-ylidene-1,3-oxathioles from aroyl dithiocarboxylates and 2-bromoacetophenone in good yields. The aroyl dithiocarboxylates were prepared by treatment of active methylene ketones with trithiocarbonate in the presence of sodium hydride. [GRAPHICS] (F) An efficient method for the synthesis of 2,4,6-triarylpyridines has been accomplished via microwave-promoted and BF3 center dot OEt2-catalyzed one-pot reaction of omega-pyrrolidinoacetophenone with chalcone. omega-Pyrrolidinoacetophenone was prepared via condensation of 2-bromoacetophenone with pyrrolidine in refluxing methanol.(8) [GRAPHICS] . |
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