Bioorganic & Medicinal Chemistry Letters ——个性化文献订阅—

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Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease

作者	Sheng, XC; Appleby, T; Butler, T; Cai, RB; Chen, XW; Cho, AS; Clarke, MO; Cottell, J; Delaney, WE; Doerffler, E; Link, J; Ji, MZ; Pakdaman, R; Pyun, HJ; Wu, QY; Xu, J; Kim, CU

选自	期刊 Bioorganic & Medicinal Chemistry Letters; 卷期 2012年22-7; 页码 2629-2634

关联知识点

[摘要]：The discovery of GS-9451 is reported. Modification of the P3 cap and P2 quinoline with a series of solubilizing groups led to the identification of potent HCV NS3 protease inhibitors with greatly improved pharmacokinetic properties in rats, dogs and monkeys. (C) 2012 Elsevier Ltd. All rights reserved.
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