Convenient Synthesis and Biological Activities of Pyridine Derivatives of 3,4-Dihydropyrimidin-2(1H)-ones

[摘要]：2-Chloro-5-(chloromethyl)-pyridine reacted with 3,4-dihydropyrimidin-2(1H)-ones 1 to afford 1-[6-aryl-1-(6-chloropyridin-3-yl-methyl)-2-(6-chloropyridin-3-yl-methyl thio)-4-methyl-1,6-dihydropyrimidin-5-yl] carboxylates or ethanones 2 in good yields. The structure of the target compounds 2 was confirmed by IR, H-1 NMR, EI-MS, and elemental analyses, and compound 2a was further characterized by single crystal X-ray diffraction. The preliminary bioassay indicated that some of the title compounds possess moderate insecticidal and fungicidal activities.

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