【文章名】Sc(OTf)(3), an efficient catalyst for addition of allyltrimethylsilane to aldehydes; Chemoselective addition to aldehydes in presence of ketones and in situ acylation (3 component coupling)
Sc(OTf)(3), an efficient catalyst for addition of allyltrimethylsilane to aldehydes; Chemoselective addition to aldehydes in presence of ketones and in situ acylation (3 component coupling)
[摘要]：Scandium triflate (2-10 mol%) has been found to be a highly efficient catalyst for the addition of allyltrimethylsilane to both activated aromatic and aliphatic aldehydes. However, deactivated (electron rich) aromatic aldehydes gave double allylated products instead. Using a stoichiometric amount of Ac2O in the allylation reaction led directly to homoallylic acetates [in situ acylation catalysed by Sc(OTf)(3)] and for the first time gave high yields of adducts with moderately electron rich aromatic aldehydes.
