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Cytotoxic Phloroglucinols from the Leaves of Myrtus communis

  作者 Cottiglia, F; Casu, L; Leonti, M; Caboni, P; Floris, C; Busonera, B; Farci, P; Ouhtit, A; Sanna, G  
  选自 期刊  Journal of natural products;  卷期  2012年75-2;  页码  225-229  
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[摘要]Bioactivity-guided fractionation of a dichloromethane extract of the leaves of Myrtus communis led to the isolation of phloroglucinol derivatives. The structures of the new myrtucommulones J, K, and L (1-3) and the previously known myrtucommulone A (4) were elucidated on the basis of extensive 1D and 2D NMR experiments as well as high-resolution mass spectrometry. Myrtucommulone J was obtained as a tautomeric pair (1/1a). The compounds were tested in vitro for their cytotoxic and antibacterial activities.

 
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