[摘要]:A simple and efficient protocol for the chemoselective mono-N-Boc protection of various structurally diverse amines with di-tert-Bu dicarbonate using 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as solvent and catalyst is described. The catalyst can be readily sepd. from the reaction products and recovered for direct reuse. No competitive side reactions such as formation of isocyanate, urea, and N,N-di-Boc were obsd. a-Amino alcs. afforded the N-Boc derivs. without oxazolidinone formation.