Synthesis of substituted monohalobenzenes via ortho-selective cross-coupling of dihalobenzenes with electron-donating ortho-directing groups.

[摘要]：Dihalobenzenes that possess directing groups such as OH, CH2OH, NH2, NHAc, or NHBoc were subjected to ortho-selective cross-coupling with Grignard reagents in the presence of palladium-based catalysts to give the corresponding substituted monohalobenzenes. For the dibromo- and dichlorophenols and anilines, hydroxylated terphenylphosphines, I, wherein R can by Cy or Ph, were found to be effective ligands for palladium, whereas tricyclohexylphosphine was preferable for the dichlorobenzyl alcs., dichloroanilides, and difluorobenzenes.

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