Analogues of oxy-heme A beta: reactive intermediates relevant to Alzheimer's disease

[摘要]：Redox active metals (Fe and Cu) and cofactors (heme) bind to A beta peptides and react with O-2 in their reduced state leading to oxidative stress in the brain. In this studywe cryogenically trap and characterize a Fe-O-2 intermediate, using resonance Raman spectroscopy, involved in reactive oxygen species formation by A beta peptides. This is the first reaction intermediate relevant to Alzheimer's disease to be reported.

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