Palladium-Catalyzed Tandem Carbocyclization-Suzuki Coupling Reactions of Trifluoromethyl-Containing Building Blocks Leading to 2-Trifluoromethylindenes

[摘要]：A palladium-catalyzed tandem carbocyclization-Suzuki coupling is described leading to the synthesis of trifluoromethyl-containing indenes in moderate to good yields. The reactions take place in the presence of palladium(II) acetate, a phosphorus-containing ligand [dicyclohexyl(2',4',6'-triisopropylbiphenyl-2-yl)phosphine] and potassium carbonate in toluene as the solvent. The process occurs via intramolecular carbocyclization and subsequent Suzuki coupling of the ortho-(2-chlorovinyl)-alkynylbenzenes with arylboronic acids.

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