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[摘要]:Optically active gamma-valerolactone and gamma-nonanolactone have been synthesized via optical resolution using a newly developed chiral airline derived from L-phenylalanine. Both racemic gamma-lactones were transformed to corresponding diastereomeric amides by amidation with the optical resolution agent. Fractional crystallization of diastereomeric amides, recrystallization of each diastereomer, and Subsequent hydrolysis gave optically active gamma-valerolactone and gamma-nonanolactone with Sufficient enantiomeric excess and isolated yield. The optical resolution agent was recovered after hydrolysis. |
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