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[摘要]:2-Mercaptopyridine-3-carboxylic acid reacts with methanol Under acidic conditions to afford the corresponding S-methylated methyl ester, methyl 2-methylthiopyridine-2-carboxylate. Such S-methylation Occurred for Various N-containing heterocyclic thiols with acidic methanol. The reaction proceeded by the attack of mercapto groups on the Conjugated acid of methanol. Therefore., the Sulfur atom of pyridine-2-thiol was also methylated with acidic methyl ethers or methyl esters. |
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