【文章名】One-Step Synthesis of Pyrido[1,2-a]benzimidazole Derivatives by a Novel Multicomponent Reaction of Chloroacetonitrile, Malononitrile, Aromatic Aldehyde, and Pyridine.
One-Step Synthesis of Pyrido[1,2-a]benzimidazole Derivatives by a Novel Multicomponent Reaction of Chloroacetonitrile, Malononitrile, Aromatic Aldehyde, and Pyridine.
[摘要]：Polysubstituted pyrido[1,2-a]benzimidazole derivs., e.g. I, are efficiently produced in moderate yields in a novel one-pot, four-component reaction from pyridine or 3-picoline, chloroacetonitrile, malononitrile, and arom. aldehydes in refluxing acetonitrile. The mechanism of this novel reaction was thought to involve formation of polysubstituted benzenes with subsequent substitution and annulation of pyridine. All pyrido[1,2-a]benzimidazoles, polysubstituted benzenes, polysubstituted indoles, and some key reaction intermediates are characterized by 1H and 13C NMR, MS, IR spectra, and elemental anal. as well as X-ray crystallog.
