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Cellular Uptake of Elastic Nanoparticles

  作者 Yi, X; Shi, XH; Gao, HJ  
  选自 期刊  PHYSICAL REVIEW LETTERS;  卷期  2011年107-9;  页码  98101-98101  
  关联知识点  
 

[摘要]A fundamental understanding of cell-nanomaterial interaction is of essential importance to nano-medicine and safe applications of nanotechnology. Here we investigate the adhesive wrapping of a soft elastic vesicle by a lipid membrane. We show that there exist a maximum of five distinct wrapping phases based on the stability of full wrapping, partial wrapping, and no wrapping states. The wrapping phases depend on the vesicle size, adhesion energy, surface tension of membrane, and bending rigidity ratio between vesicle and membrane. These results are of immediate interest to the study of vesicular transport and endocytosis or phagocytosis of elastic particles into cells.

 
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