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Domino Ligand-Free Copper-Catalyzed Synthesis of Polysubstituted Indoles

  作者 ALI MD ASHIF; PUNNIYAMURTHY THARMALINGAM  
  选自 期刊  SYNLETT;  卷期  2011年-5;  页码  623-626  
  关联知识点  
 

[摘要]The synthesis of polysubstituted indoles is described by the domino reaction of 2-haloanilines and 1,3-dicarbonyl compounds, 1,3-diketones, beta-keto esters and beta-keto amides, using copper catalysis under ligand-free conditions. The protocol provides a simple, general and atom economical process for the synthesis of substituted indoles at moderate temperature.

 
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