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Synthesis of 2-Aryl-1,2-dihydrophthalazines via Reaction of 2-(Bromomethyl)benzaldehydes with Arylhydrazines

  作者 ALJAAR NAYYEF; CONRAD JUERGEN; BEIFUSS UWE  
  选自 期刊  Journal of Organic Chemistry;  卷期  2013年78-3;  页码  1045-1053  
  关联知识点  
 

[摘要]The reaction of 2-(bromomethyl)benzaldehydes with arylhydrazines employing K2CO3 as a base and FeCl3 as a catalyst in CH3CN at 100 degrees C delivers 2-aryl-1,2-dihydrophthalazines with yields ranging from 60 to 91%. The transformation is considered to proceed as an intermolecular condensation/intramolecular nucleophilic substitution.

 
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