Synthesis of 1,5-Disubstituted 1H-Tetrazole Derivatives via a Three-Component Reaction of Carbodiimides, Isocyanides, and Trimethylsilyl Azide

[摘要]：The three-component reaction of isocyanides 1, carbodiimides 2, and trimethylsilyl azide (3) occurs at room temperature, and the produced 1,5-disubstituted 1H-tetrazole derivatives 4 are formed in 8198% yields (Scheme 1, Table). The reaction proceeds smoothly and cleanly under mild conditions, and no side reactions are observed.

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