Stereocontrolled Synthesis of 5 '- and 6 '-Epimeric Analogues of Muraymycin Nucleoside Antibiotics

[摘要]：Naturally occurring nucleoside antibiotics, for example, Streptomyces-produced muraymycins, represent a promising class of potential lead structures for the development of novel antimicrobial agents. The efficient preparation of muraymycin analogues is an essential prerequisite for detailed structure-activity relationship (SAR) studies, particularly with respect to the variation of the stereochemistry in a controlled manner. In this work, stereoselective syntheses of 5'- as well as 6'-epimers of muraymycins are reported. The obtained target structures also represent useful probes for the elucidation of the biosynthesis of muraymycins and related nucleoside antibiotics.

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