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Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors

  作者 Rajamaki, S; Innitzer, A; Falciani, C; Tintori, C; Christ, F; Witvrouw, M; Debyser, Z; Massa, S; Botta, M  
  选自 期刊  Bioorganic & Medicinal Chemistry Letters;  卷期  2009年19-13;  页码  3615-3618  
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[摘要]A novel compound inhibiting HIV-1 integrase has been identified by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with some of the compounds possessing micromolar activity both in enzymatic and cellular assays. (C) 2009 Elsevier Ltd. All rights reserved.

 
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