SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME N-ACYL-2,6-DIAMINOPYRIDINES AND RELATED LINKER MODE IDENTICAL TWIN DRUGS

[摘要]：In connection with our studies on biologically active compounds in the class of N-acyl-2,6-diaminopyridines, some molecular modifications were attempted. All of the synthesized compounds were evaluated for biological activity with herpes virus type 1 (HSV-1) by a plaque reduction assay. We observed that most of the synthesized derivatives showed no significant anti-HSV-1 activity, but we found that compounds 5 and 6 with a branched long alkyl chain showed high cytotoxicity to Vero cells.

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