Studies Directed Towards the Synthesis of Bryostatin: A Stereoselective Synthesis of the C7-C16 Fragment

[摘要]：A stereocontrolled asymmetric synthesis of the C7-C16 fragment of bryostatins is described. The key steps involved were a Jacobsen's hydrolytic kinetic resolution and a Reformatsky reaction to build the C11-C16 fragment. A vinyl Grignard reagent was used to construct the C7-C10 fragment. The C11-C16 and C7-C10 fragments were coupled by means of a cross-metathesis reaction to give a key intermediate. The pyran ring system was constructed by means of an oxa-Michael reaction.

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