A Convergent Synthesis of Chiral Diaminopimelic Acid Derived Substrates for Mycobacterial L, D-Transpeptidases

[摘要]：Amidated and deamidated chiral DAP-D-Ala analogues were prepared by olefin cross-metathesis of 12 with modified D-allylglycines using Grubbs' 2nd generation catalyst. Hydrogenation and deprotection of these precursors provided four chiral (2S, 6R)-DAP-D-alanine derivatives that were examined as substrates for Mtb L, D-transpeptidases in a C-14-D-Ala exchange reaction.

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