[摘要]：Platensimycin and platencin are novel natural product antibiotics that inhibit bacterial growth by inhibiting condensing enzymes FabF and FabF/FabH of fatty acid biosynthesis pathways, resp. Continued search for the natural congeners of these compds. led to the isolation of platensic acid, the free C-17 tetracyclic enoic acid, and platensimide A, a 2,4-diaminobutyric acid amide deriv. Isolation, structure, semisynthesis, and activity of these compds. are described.
