Acyl Radicals from Nitriles Promoted by Cp2TiCl in beta-Lactam Chemistry

[摘要]：In order to synthesize new tricyclic beta-lactams we have studied the reactivity of 4-alkenylepoxy-N-(1-cyano-1-dimethyl-ethyl)-2-azetidinones with Cp2TiCl. The desired trilactams were not formed at all but an unsaturated nitrile and an aldehyde were obtained instead. Under similar reaction conditions, the treatment of styrylnitrile with Cp2TiCl afforded the styrylaldehyde. The formation of aldehydes in these reactions suggest the generation of acyl radicals from nitriles mediated by Cp2TiCl.

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