Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones

[摘要]：

A series of thirteen 4,5-diaryl-3-hydroxy-2(5H)-furanones were synthesized. They were evaluated for their antioxidant potencies and inhibitory properties of 5-lipoxygenase, cyclooxygenases, HIV-1 integrase and PC3 cell proliferation. New hits were discovered either in the anti-proliferation test or in the HIV anti-integrase test. (c) 2007 Elsevier Masson SAS. All rights reserved.

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