Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones

[摘要]：

Seven hydroxyanthraquinone derivatives, 1-7, were isolated from the root of Rheum palmatum (Polygonaceae). Two propionated anthraquinone derivatives, 8 and 9, were synthesized. Four hydroxynaphthoquinone derivatives, 13, 14, 16 and 21, were isolated from the root of Lithospermum erythrorhizon Sieb. et Zucc. (Boraginaceae) and also three naphthoquinone derivatives, 19, 22 and 23, were isolated from the root of Macrotomia euchroma (Royle) Pauls. (Boraginaceae). The cytotoxicity of the anthraquinone and naphthoquinone derivatives on P-gp-underexpressing HCT 116 cells and P-gp-overexpressing Hep G2 cells was examined by MTT assay. Among the anthraquinone derivatives, compounds 3-5 which had OH, CH2OH and COOH substituent groups on the anthraquinone skeletons, respectively, showed potent growth inhibitory activities against both types of cancer cells (IC50 values: 5.7 +/- 0.9 to 13.0 +/- 0.7 mu M in the case of HCT 116 cells and 5.2 +/- 0.7 to 12.3 +/- 0.9 mu M in the case of Hep G2 cells). All hydroxynaphthoquinone derivatives isolated in this study exhibited extremely potent growth inhibitory activities against both types of cancer cells (IC50 values: 0.3 +/- 0.09 to 0.46 +/- 1.0 mu M in the case of HCT 116 cells and 0.22 +/- 0.03 to 0.59 +/- 0.06 mu M in the case of Hep G2 cells) as well as shikonin 10 (IC50 values: 0.32 +/- 0.02 mu M in the case of HCT 116 cells and 0.24 +/- 0.03 mu M in the case of Hep G2 cells). (c) 2007 Elsevier Masson SAS. All rights reserved.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内