Catalytic Asymmetric 6 pi-Electrocyclization: Accessing Highly Substituted Optically Active 2-Pyrazolines via Diastereoselective Alkylations

[摘要]：The chiral phosphoric acid catalyzed asymmetric electrocyclization of alpha,beta-unsaturated hydrazones has been studied. This reaction is one of the first catalytic asymmetric 6 pi-electrocyclizations reported, and enables the synthesis of 2-pyrazolines in high yields and enantiomeric ratios. The obtained products are not only interesting because of their pharmaceutical properties, but can be manipulated in highly diastereoselective fashion, as shown for alkylation reactions. Thus, the combination of catalytic asymmetric 6 pi-electrocyclization followed by diastereoselective alkylation can provide interesting synthetic building blocks in optically active form.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内