【文章名】Stereoselective Synthesis of trans-Fused 7,6,6,7-Membered Tetracyclic Ether, Corresponding to the EFGH-Ring of Gambierol and the BCDE-Ring of Gambieric Acids.
Stereoselective Synthesis of trans-Fused 7,6,6,7-Membered Tetracyclic Ether, Corresponding to the EFGH-Ring of Gambierol and the BCDE-Ring of Gambieric Acids.
[摘要]：Stereoselective synthesis of a trans-fused 7,6,6,7-membered tetracyclic ether (I), corresponding to the EFGH-ring of gambierol and the BCDE-ring of gambieric acids, was efficiently accomplished via a two-directional approach. The key reactions were SmI2-induced double cyclization for construction of the F- and H-rings and SmI2-induced cyclization followed by ring expansion for construction of the E-ring.
