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[摘要]：(Biomolecules and Their Synthetic Analogs) Section A review. Recent research on the chem. of natural products from the author's group that led to the receipt of the ACS Ernest Guenther Award in the Chem. of Natural Products is reviewed. REDOR NMR and synthetic studies established the T-taxol conformation as the bioactive tubulin-binding conformation, and these results were confirmed by the synthesis of compds. which clearly owed their activity or lack of activity to whether or not they could adopt the T-taxol conformation. Similar studies with the epothilones suggest that the current tubulin-binding model needs to be modified. Examples of natural products discovery and biodiversity conservation in Suriname and Madagascar are also presented, and it is concluded that natural products chem. will continue to make significant contributions to drug discovery. |
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