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[摘要]：An efficient microwave-assisted synthesis of 1-carboxymethyl-5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazoles from the cyclocondensation reaction between enones [CF3C(O)C(R-2) = C(R-1)(OR), where R-2 = H. Me; R-1 = H. Me, Et, Pr, i-Pr, t-Bu, i-Bu. Ph, 4-NO2-Ph, 4-Cl-Ph, 4-Br-Ph, 4-F-Ph and R = Me, Et] and methyl hydrazinocarboxylate under solvent-free conditions is reported. This process is an efficient alternative to the traditional thermal heating and furnishes the heterocyclic compounds in good to excellent yields in a short reaction time. To show the versatility of 1-carboxymethyl-5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazoles, dehydration reactions of these compounds are also demonstrated. |
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