Chiral Thiourea-Catalyzed Asymmetric Michael Addition of beta-Oxo Phosphonate to Nitro Olefins: Convenient Synthesis of Optically Active beta-Oxo Phosphonates

[摘要]：beta-Oxo phosphonates have been proven to be alternative Michael donors in Michael addition reactions to nitro olefins in the presence of cinchonine-based bifunctional thiourea, affording a direct and atom-economic approach to the efficient construction of synthetically and biologically valuable chiral acyclic alpha-substituted beta-oxo phosphonates with high levels of enantioselectivity (up to 98% ee).

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