A Tandem Isomerization-Mannich Reaction for the Enantioselective Synthesis of beta-Amino Ketones and beta-Amino Alcohols with Applications as Key Intermediates for ent-Nikkomycins and ent-Funebrine

[摘要]：beta-Amino ketones, with a primary amino group, are easily obtained in good yields and excellent enantioselectivities through a short sequence that involves, as a key step, a tandem isomerization-Mannich reaction from allylic alcohols with N-tert-butanesulfinimines. This method was used for the enantioselective synthesis of corresponding beta-amino alcohols and also for key intermediates in the preparation of ent-nikkomycins or ent-funebrine.

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