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[摘要]：The click synthesis of some novel O-substituted oximes, 7a7t, which contain 1,2,3-triazolediyl residues, as new analogs of beta-adrenoceptor antagonists is described (Schemes 14). The synthesis of these compounds was achieved in four to five steps. The formation of oximes of 9H-fluoren-9-one and benzophenone, i.e., 9a and 9b, respectively, followed by their reaction with propargyl bromide, afforded O-propargyl oximes 10a and 10b, respectively, which by a subsequent CuI-catalyzed Huisgen cycloaddition with prepared beta-azido alcohols 11a11j (Schemes 2 and 3), led to the target compounds 7a7t in good yields. |
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