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"One-Pot" Tandem C-H Borylation/1,4-Conjugate Addition/Reduction Sequence

  作者 TAJUDDIN HAZMI; SHUKLA LENA; MAXWELL AOIFE C; MARDER TODD B; STEEL PATRICK G  
  选自 期刊  Organic Letters;  卷期  2010年12-24;  页码  5700-5703  
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[摘要]A microwave-assisted, one-pot, iridium-catalyzed aromatic C-H borylation/rhodium-catalyzed 1,4-conjugate addition sequence provides a highly robust protocol suitable for high-throughput array synthesis. Selective formation of either beta-aryl-substituted ketones or the corresponding alcohols can be achieved in good overall yields by simple variation of the reaction conditions.

 
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