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Catalytic Asymmetric Domino Michael Addition-Alkylation Reaction: Enantioselective Synthesis of Dihydrofurans

  作者 RUEPING MAGNUS; PARRA ALEJANDRO; URIA UXUE; BESSELIEVRE FRANCOIS; MERINO ESTIBALIZ  
  选自 期刊  Organic Letters;  卷期  2010年12-24;  页码  5680-5683  
  关联知识点  
 

[摘要]A catalytic enantioselective synthesis of dihydrofurans has been developed. 1,3-Dicarbonyl derivatives react with (E)-beta,beta-bromonitrostyrenes in the presence of a chiral bifunctional thiourea catalyst providing mild and efficient access to diverse polysubstituted dihydrofurans in good yields and enantioselectivities.

 
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