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Furo[3,4-b]chromones, and not Pyrano[3,4-b]chromones, are Obtained by the Reaction of 3-Formylchromones with Isocyanides

  作者 NEO ANA G; GARRIDO LEDA; DIAZ JESUS; MARCACCINI STEFANO; MARCOS CARLOS F  
  选自 期刊  SYNLETT;  卷期  2012年-15;  页码  2227-2230  
  关联知识点  
 

[摘要]The reaction of formylchromones with alkyl isocyanides was reinvestigated. In earlier reports from other research groups, two different structures were proposed for the products of this reaction. Herein, we provide unambiguous evidence that these products are chromenylmethylene furochromenones and not pyranochromones. Our structure assignment is based on X-ray diffraction analysis and two-dimensional NMR methods. The knowledge of the correct structure of these compounds is essential for the design of derivatives with potential applications as bioactive molecules or fluorescent biomarkers.

 
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