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[摘要]：Stereoselective syntheses of two 3-O-Gal sulfated trisac-charides GalNAc beta(1-4)[(3-SE)-Gal]beta(1-3)GalNAc alpha-O-All and GalNAc beta(1-4)[(3-SE)-Gal]beta(1-4)Glc beta-O-All were accomplished through the use of three novel glycosyl acceptors, namely, allyl 4,6-O-benzylidene-2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-alpha-D -galactopyranoside, methyl 2,6-di-O-benzoyl-3-O-naphthylmethyl-alpha-D-galactopyranoside and allyl 6-O-acetyl-2-O-benzoyl-3-Onaphthylmethyl-beta-D-galactopyranosyl-(1 -> 4)-2,3,6-tri-O-benzoyl-beta-D-glucopyranoside. These sulfated trisaccharides were expected to act as potential reference compounds for human beta 4GalNAc transferase and can be effectively used as antigens when linked to KLH. |
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